Sentinel Node Biopsy Guideline

This guideline is the product of a meeting that took place in Cambridge in May 2018, organised by Melanoma Focus and chaired by Mr Howard Peach. It involved some 70 clinicians, nurses and patient representatives, who came together to consider issues surrounding sentinel lymph node biopsy and completion lymph node dissection. Three main areas were addressed: oncology, surgery and pathology.

Click here to download the document in pdf format.

Mr Howard Peach, a plastic surgeon at Leeds Teaching Hospitals NHS Trust and a Trustee of Melanoma Focus, who chaired the Consensus group, said: ‘With the changes in melanoma management that have taken place in recent years, it was time to re-visit the whole question of the role of sentinel node biopsy (SNB) in the treatment and prognosis of melanoma patients. We have drawn on key findings from a number of recent clinical trials in developing, for the first time, a formal set of recommendations for clinical practice in the UK.

‘The introduction of effective adjuvant therapy for melanoma has changed the primary role of SNB: from a prognostic indicator to one that now influences access to this form of therapy. Aligned with this change is the role of completion lymph node dissection (CLND) following a positive biopsy of the sentinel lymph nodes. Since defining the specific group of people who might benefit from this procedure has been difficult, CLND has routinely been recommended for all. However the results of two large international trials – and the availability of drug therapy for patients who develop a recurrence – have changed international opinion. It was therefore agreed that CLND should NOT be recommended routinely for patients who have a positive SNB.

‘We hope this evidence-based and considered guidance will help healthcare professionals when they advise patients on their treatment options’.

Please email rodwell@melanomafocus.com if you have any queries or comments.

Melanoma Focus is grateful to the authors, who are listed at the end of the document, and all those who gave generously of their time in developing and reviewing the guideline.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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