Mucosal Melanoma Guidelines Project

Phase II: Sino-Nasal/Head & Neck Mucosal Melanoma Guideline Project –
Invitation for Expressions of Interest in Joining Development Group

Melanoma Focus is preparing to set up a Guideline Development Group (GDG) to produce a national clinical guideline for sino-nasal/head & neck mucosal melanoma.


Mucosal melanomas are rare, representing only about 1-2% of all melanomas. 55% of all primary mucosal melanomas occur in the head and neck region, with the nose and paranasal sinuses being the most common sites. Surgery at all stages frequently involves complex decisions about risk and benefit, and the value of adjuvant treatment – drug therapy or radiotherapy – is unclear. Medical treatment of advanced melanoma is evolving rapidly and its relevance to this group of patients requires clarification. There is no agreement about diagnostic imaging techniques or follow-up protocols. There is therefore a need for clinical guidance in this area.

As the principal UK melanoma charity, Melanoma Focus has a remit to lead in the development of clinical guidance for melanoma and is well-placed to sponsor the production of a guideline for sino-nasal/head & neck mucosal melanoma. This guideline will be developed in compliance with NICE accreditation requirements and published in relevant medical journals.

This initiative follows the charity’s support for the successful development of guidelines for uveal melanoma and ano-uro-genital mucosal melanoma. Melanoma Focus has NICE accreditation for its guideline methodology – see Guideline Development Methodology.

Composition and work of the GDG

The GDG will be led by Professor Kevin Harrington, with project management and methodological support & funding by Melanoma Focus. It will comprise approximately 12 members from appropriate specialisations and interests:

• Maxillofacial/Head & Neck Surgeon
• ENT Surgeon
• Oral & Facial Plastic Surgeon
• Medical Oncologist with an interest in melanoma
• Clinical Oncologist with an interest in head and neck oncology
• Surgeon with a major interest in melanoma
• Pathologist with expertise in melanoma and head and neck oncology
• Radiologist with expertise in melanoma and head and neck oncology
• CNS specialising in head and neck cancers
• CNS specialising in melanoma
• Patient Advocates/Representatives

Please pass this information on to colleagues or lay representatives who may be interested in this initiative.

Members will contribute to the group as individuals, drawing on their own areas of experience, rather than representing any particular organisation. The work will consist of:

• Contributing to the review of evidence and the drafting of the guideline within their area of expertise.
• Preparing for the topics to be discussed at the meetings. For each meeting, members will be expected to read through the papers, including evidence reviews, which will take approximately 2-4 hours.
• Contributing to the discussions, taking full account of the evidence to develop recommendations.
• Assisting with the drafting of the final guideline following the consultation phase.

GDG members will be expected to give this work their highest priority and to attend all the GDG’s meetings. Only those who are able to make such a commitment should apply. Members will be cited as co-authors of the guideline in resulting publications.


We expect the process to take 18-24 months and involve 9 to 12 one-day meetings in London. The first meeting of the GDG is planned for 25 May.


No fees will be paid but reasonable out-of-pocket and travel expenses will be reimbursed by Melanoma Focus.

How to apply

We now invite expressions of interest from people with requisite experience who would like to be considered for membership of the Sino-Nasal/Head & Neck Mucosal Melanoma GDG.

If you are interested in being considered or have any queries please email Nancy Turnbull, Project Manager, at We will send you an application form to record your professional details and the reasons for your interest. The deadline for the receipt of completed applications is 23 March.


Phase I: Ano-uro-genital Mucosal Melanoma Guideline Project

The Guideline Development Group that has been developing UK clinical guidelines for ano-uro-genital mucosal melanoma on behalf of Melanoma Focus is now writing up its conclusions following a successful consultation process during September and October 2017. The final guidelines and supporting material will be made available on this website.

Although the consultation phase is now over you can still view the draft document – please follow the links below for:


The Guideline Development Group (GDG), set up by Melanoma Focus in 2016, consists of clinicians specialising in medical & clinical oncology, surgery, gynaecology, radiology and histopathology, as well as a nurse and a patient representative. The first guideline addresses ano-uro-genital melanoma. This will be followed by a guideline concentrating on sino-nasal melanoma.

Given the disease’s rarity, no randomised controlled trials have been identified for mucosal melanoma, but there is a large body of information relating treatments to outcomes. The challenge has been to identify the relevance of the published data to current clinical practice and produce agreed recommendations to guide healthcare professionals and inform patients and their carers.

The GDG is led by Professor Martin Gore, with project management and methodological support provided by the Project Manager, Mrs Nancy Turnbull.

This initiative follows the charity’s support for a group that successfully developed guidelines for uveal melanoma, receiving accreditation from The National Institute for Health and Care Excellence (NICE) in January 2015 (click here for further information).

The Mucosal Melanoma Guidelines were developed in accordance with a Melanoma Focus manual, Guideline Development Methodology. The Melanoma Focus development methods have been accredited by NICE as complying with their AGREE II criteria for the rigorous development of evidence-based guidelines. This replaces the methodology used in the drafting of the Uveal Melanoma Guidelines.

Membership of the Ano-Uro-Genital Mucosal Melanoma Guideline Development Group

Professor Martin Gore Consultant Medical Oncologist and GDG Chairman Royal Marsden NHS Foundation Trust
Dr Izhar Bagwan Consultant Histopathologist Royal Surrey County Hospital NHS Foundation Trust
Dr Ruth Board Consultant Medical Oncologist Lancashire Teaching Hospitals NHS Foundation Trust
Miss Sharon Capper Macmillan Urology Clinical Nurse Specialist Christie NHS Foundation Trust
Professor Sarah Coupland Honorary Consultant Histopathologist University of Liverpool
Dr Susan Lalondrelle Consultant Clinical Oncologist Royal Marsden NHS Foundation Trust
Ms Antonia Mayberry Patient Representative Rochdale
Mr Asif Muneer Consultant Urological Surgeon & Andrologist University College London Hospitals NHS Foundation Trust
Ms Karen Nugent Honorary Consultant Colorectal Surgeon University Hospital Southampton NHS Foundation Trust
Mr Pubudu Pathiraja Consultant in Gynaecology Oncology Oxford University Hospitals NHS Foundation Trust
Dr Miranda Payne Consultant Medical Oncologist Oxford University Hospitals NHS Foundation Trust
Mr Howard Peach Consultant Plastic & Reconstructive Surgeon Leeds Teaching Hospitals NHS Trust
Mr Henry Smith Research Fellow and Rapporteur of the Guideline Development Group Royal Marsden NHS Foundation Trust
Dr Jonathan Smith Consultant Radiologist Leeds Teaching Hospitals NHS Trust
Mr Myles Smith Consultant General Surgeon & Surgical Oncologist Royal Marsden NHS Foundation Trust
Dr Sarah Westwell Consultant Clinical Oncologist Brighton and Sussex University Hospitals NHS Trust
Mr Ewan Wilson Consultant Plastic & Reconstructive Surgeon North Bristol NHS Trust
Mr Simon Rodwell Chief Executive Melanoma Focus
Mrs Nancy Turnbull Project Manager

Melanoma Focus is extremely grateful to the group for their generous donation of skill, time and effort.




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